Abstract
Prunus africana is one of the most popular to treat benign prostate hyperplasia (BHP), and to treat diarrhoea, dysmenorrhoea, infertility, irregular menstruation, kidney disease, disorders, fevers, obesity, pneumonia, hypertension, antigonorrheic, antimalarial, chest pain; other various diseases. The air dried and powdered plant material (200g) was first soaked with 500 mL n-hexane for 72 hours and yielded 1.3 g of n-hexane extract. Marc was soaked with 400 mL of ethyl acetate for 72 hours and afforded 2g of ethyl acetate extract. Finally, Marc was soaked with 400mL of methanol and yielded 12.6 g of methanol extract. The ethyl acetate extract of the root bark of P. africana afforded a compound coded as AYU . Its Structural determination was accomplished by means of spectroscopic techniques, namely IR, 1 H NMR, 13 C NMR and DEPT-135. The compound, AYU was isolated and characterized from the root bark of P. african . It was shown that spot on TLC only up on spraying 1% vanillin sulphuric acid and after heating for a few minutes. Generally, chromatographic techniques like PTLC and HPLC are required to isolate more compounds from leaves of P. africana . Also MS and 2D NMR spectroscopic techniques are needed to fully characterize the isolated compound. Keywords: P.africana; benign prostate hyperplasia; characterization; chromatographic techniques; spectroscopic techniques. DOI: 10.7176/CMR/12-6-02 Publication date: July 31 st 2020
Highlights
Plants have long history of being used for a wide variety of purposes including food, clothing, shelter, tools, weapons, and therapeutic agents.[1] phytochemical study of plants is of the great importance in developing drugs.Drugs are strictly defined as chemical substances that are used to prevent or cure diseases in humans, animals and plants
According to the World Health Organization (WHO) estimation that around 80% of the world population in developing countries relies on traditional medicines for primary health care needs, of which a major proportion corresponds to plant extracts.[2]
The World Health Organization has recognized the importance of traditional medicine and has created strategies, guidelines and standards for botanical medicines.[3]
Summary
Plants have long history of being used for a wide variety of purposes including food, clothing, shelter, tools, weapons, and therapeutic agents.[1] phytochemical study of plants is of the great importance in developing drugs.Drugs are strictly defined as chemical substances that are used to prevent or cure diseases in humans, animals and plants. Drugs from natural products are secondary metabolites and their derivatives. Natural product chemistry is a part of organic chemistry that covers the chemistry of naturally occurring organic compounds: their biosynthesis, function in their environment, metabolism and more conventional branches of chemistry such as structural elucidation and synthesis. Secondary metabolism refers to the functions of an organism yielding products that are not necessary for the essential biochemical events. According to the World Health Organization (WHO) estimation that around 80% of the world population in developing countries relies on traditional medicines for primary health care needs, of which a major proportion corresponds to plant extracts.[2] The World Health Organization has recognized the importance of traditional medicine and has created strategies, guidelines and standards for botanical medicines.[3] From 70-95%
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