Abstract
Cinnamomum yabunikkei H.Ohba leaf is known as a traditional medicinal material in Korea. However, no scientific identification of the components or efficacy of C.yabunikkei H.Ohba leaf has been reported. In the present study, we prepared various solvent extracts of C.yabunikkei H.Ohba leaf to understand its basic properties and evaluated the antioxidant, xanthine oxidase inhibitory, and elastase inhibitory activities of hexane, ethyl acetate, acetone, methanol, ethanol, and water extracts for the first time. The antioxidant properties were evaluated based on 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity, reducing power, and total phenolic contents. The hot water extract showed the highest DPPH radical scavenging activity and total phenolic contents, and the reducing power was the highest in the water extract. The hexane extract showed an excellent elastase inhibitory effect compared to control (phosphoramidone) and the highest xanthine oxidase inhibitory activity. These results present basic information for the possible uses of the hot water and hexane extracts from C. yabunikkei leaf for the treatment of diseases caused by oxidative imbalance. In the present study, individual extracts exhibited different effects. Therefore, it is hypothesized that the applicability of C. yabunikkei will depend on the extraction method and nature of the extract. The hot water and hexane extracts could be used as antioxidants, and as anti-gout and anti-wrinkle materials respectively. Several biologically active substances present in hexane extract of C. yabunikkei have been analyzed by GCMS and demonstrated to possess antioxidant and xanthine oxidase inhibitory activity. To the best of our knowledge, this is the first study that reports the chemical profiling and biological effects of various C. yabunikkei leaf extracts, suggesting their potential use in food therapy, cosmetics or alternative medicine.
Highlights
Cinnamomum yabunikkei H.Ohba is a species of camphor tree native to the southern coast and JejuIsland in South Korea and can be seen in southern China and Taiwan
Due to the acceleration in global warming, the southern part of South Korea has experienced the cultivation of C.yabunikkei H.Ohba, studies dealing with the possibilities of using C.yabunikkei
The results indicate that the DPPH radical scavenging radical scavenging activity,and power reduction, and phenolic reduction were significantly activity, power reduction, phenolic contents reductioncontents were significantly higher in the hothigher water in the hot water extract as compared to other extracts
Summary
Cinnamomum yabunikkei H.Ohba is a species of camphor tree native to the southern coast and Jeju. The components of the leaves of C.yabunikkei have not been identified and biological activity studies have not been conducted. To the best of our knowledge, this is the first report to understand the composition and biological activity of the C.yabunikkei leaf. Various extracts of the C.yabunikkei leaf using hexane, ethyl acetate, acetone, ethanol, methanol, and hot water were prepared to determine the optimal extraction solvent with ethanol, methanol, and hot water were prepared to determine the optimal extraction solvent with respect to biological activity and phytochemical profiles. Antioxidant, xanthine oxidase inhibitory, and elastase inhibitory activity of the leaf extracts were examined. The antioxidant oxidase inhibitory, and elastase inhibitory activity of the leaf extracts were examined.
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