Abstract
Ferula assafoetida L. (resin), Zingiber officinale (rhizome), and Glycyrrhiza glabra (root) are used together in traditional medicine as “Chitrakadivati” for the treatment of flatulence, gut microflora, and indigestion. Scientific studies validating therapeutic properties for this indigenous medicine are lacking. This study focused on determining the antimicrobial efficacies of methanolic extracts of these plant parts independently and in combination by measuring the zone of inhibition and minimum inhibitory concentration. Antimicrobial activity was tested against bacteria: Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis, Styphylococcus aureus, Bacillus cereus, Proteus vulgaris; fungi: Aspergillus flavus, Aspergillus niger, Pencillium Sp, Candida albicans, and an, Beauveria bassiana. The zones of inhibition of individual extracts are lower (0–15 mm) against microbes than in combination (9–23mm). Preliminary phytochemical analysis showed the presence of reducing sugars, cardiac glycosides, terpenoids, carbonyls, flavonoids, tannins, and phenolics. This investigation provides evidence of synergism among the phytochemcials when used in combination.
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