Abstract
Pterospartum tridentatum and Mentha pulegium are largely used in Portuguese folk medicine to treat several human disorders and inflammatory processes but without any consistent evidence for those beneficial pointed properties. Thus, the aim of the current work is to evaluate its benefits and phytochemicals related to those beneficial properties. A distinct polyphenol profile between P. tridentatum and M. pulegium was found. Taxifolin, myricetin, ginestin, ginestein, and ginestein derivatives, biochanin A-glucoside, and biochanin A were identified in P. tridentatum, whilst in M. pulegium the luteolin-7-rutinoside, diosmin, and apigenin and respective derivatives were most representative polyphenols. These variations had implications in the antiradical and antibacterial activity and the P. tridentatum exhibited the highest antibacterial activity against methicillin-resistant and methicillin-sensitive Staphylococcus aureus MSSA, which was mainly dose-dependent. This antibacterial activity seems to be related to high content of flavonols, flavones, and isoflavones, which can act synergistically with each other against this type of bacteria. Our results showed consistent evidence that Pterospartum tridentatum and Mentha pulegium are an important reservoir of phytochemicals with antiradical activity and antibacterial capacity and thus they might be used in a preventive way or in a combined pharmaceutical and antibiotic therapy against pathogenic bacteria.
Highlights
Nowadays, one key problem in human health is the less effectiveness of commercial antibiotics against several pathogenic bacterial isolates
We set this study in which we evaluate the phytochemical composition of P. tridentatum and M. pulegium and its effect on the antioxidant activity and antimicrobial potential against different isolates of Staphylococcus aureus, an important pathogen highly associated with outbreak diseases and antibiotic resistance phenomena
The polyphenol profile and respective chemical structures of phenolics identified in the current study of hydroalcoholic extracts from P. tridentatum and M. pulegium are presented in Figures 1 and 2
Summary
One key problem in human health is the less effectiveness of commercial antibiotics against several pathogenic bacterial isolates. Different authors have shown that plants have naturally bioactive compounds that could act alone or in synergy with antibiotics against bacterial isolates [7, 8] and BioMed Research International the aromatic and medicinal plants have been one of the most studied plants and found useful as antibacterial, antifungal, and antihelminthic [9,10,11] among other beneficial properties. We set this study in which we evaluate the phytochemical composition of P. tridentatum and M. pulegium and its effect on the antioxidant activity and antimicrobial potential against different isolates of Staphylococcus aureus, an important pathogen highly associated with outbreak diseases and antibiotic resistance phenomena
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