Abstract
Desmodium gangeticum (L.) DC. is a well explored traditional Indian medicinal plant used to treat neurological imbalances. Recent pharmacological studies established its multi-directional therapeutic significance as anti-leishmanial, anti-inflammatory, cardio-protective drug. Moreover, it has detoxifying, blood purification property which might be attributed to its immunomodulatory activity. Phytochemical research revealed the plant is rich in alkaloids, pterocarpans, phospholipids, sterols and flavanoids. The review emphasizes primarily on folkloric uses, pharmacological activities of the extracts, biological activities of isolated compounds, toxicity and safety profile of Desmodium gangeticum to provide a comprehensive data for researchers to hit upon new chemical entity responsible for its claimed traditional uses and further clinical trials.
Highlights
Desmodium gangeticum (D. gangeticum) (L.) DC. (Family: Fabaceae) commonly known as Shalaparni is an important species of the genus Desmodium
The results showed flavanoids fraction possessed potent antioxidant activity compared to alkaloid fraction 30
Glyco-lipids viz. Aminoglucosyl glycerolipid and glycosphingolipid, isolated from the roots of D. gangeticum showed potent antileishmanial and immunomodulatory activities in-vitro by enhancing nitric oxide (NO) production and provided resistance against infection established in peritoneal macrophages by the protozoan parasite Leishmania donovani[37]
Summary
Desmodium gangeticum (D. gangeticum) (L.) DC. (Family: Fabaceae) commonly known as Shalaparni is an important species of the genus Desmodium. (Family: Fabaceae) commonly known as Shalaparni is an important species of the genus Desmodium. D. gangeticum is a sub-tropical perennial herb grows in dry hill areas, mainly in the basement of Westernghat region and Himalayan territory. It is sweet in taste and mild warming in action[2]. The roots are used as expectorant and in snake bite and scorpion sting[4]. It is an ingredient of Ayurvedic preparations like ‘Dashmoolarishta’ and ‘Dashmoolakwaath’ recommended for post-natal care to avoid secondary complications[5].
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