Abstract
ABSTRACTPhytochemical screening assay on crude extracts of Ocimum tenuiflorum L. leaves and methanol fractions was performed in this study. Phytochemical qualitative assay on aqueous crude extract and aqueous fraction did not show any steroid and terpenoid. However, ethanol and butanol fractions also did not show steroid in the screening test. The result of HPLC identification of active crude extracts and active fractions showed the possible bioactive compounds in this plant extracts, which may control diabetes. These findings showed that the active crude extract (methanol) and its active fractions (ethyl acetate, and butanol) showed the presence of polyphenolic active constituents such as 3,4-dimethoxycinnamic acid, caffeic acid, diosmetin, luteolin, kaempferol, rosmarinic acid, apigenin, and genistein that control the blood glucose in diabetic rats. Furthermore, isolation of the active components may pave the way for the development of new agents for the treatment of diabetes and its complications.
Highlights
In the developing world, plant-based traditional medicines are demanded by approximately 3.4 billion people
This number makes up 88% of the overall inhabitants in the world, where traditional medicine is their main approach for primary health care
Most of the time, these bioactive components or non-nutrient plant chemical compounds are known as phytoconstituents (‘phyto-‘means ‘plant’ in Greek) or phytochemicals
Summary
Plant-based traditional medicines are demanded by approximately 3.4 billion people. The quality of element and active constituent’s content of herbal medicine are depending on numerous factors These include choosing the highest yielding age, geographical origin (climatic variation), growth conditions, genetic composition of the plant, variety, plant species, and particular parts of the plants which are harvested before getting processed.[3] There are several major groups of compounds which play a role in the phytomedicine activity from plants. These include alkaloids, terpenoids, coumarins, tannins, flavonoids, saponins, quinones, phenolic acids, and phenolics.[3] Of all these compounds, alkaloids are the largest group of secondary chemical constituents with a high content of ammonia compounds. It is possible that the roles of Cinnamon polyphenols are numerous as anti-inflammatory and/or anti-angiogenesis agents.[7]
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