Abstract
The investigation into promising botanical materials for natural cosmetics is expanding due to environmental and health awareness. Here, we aimed to evaluate the phytochemical substances and the potential skin-related pharmacological activities of four Mucuna seeds, namely M. gigantea (Willd.) DC. (MGG), M. interrupta Gagnep. (MIT), M. monosperma Wight (MMM), and M. pruriens (L.) DC. (MPR), belonging to the Fabaceae family. In methodology, the Mucuna seeds were authenticated using morphological and molecular approaches. L-DOPA, phenolics, and flavonoid content, incorporated with HPLC and GC–MS fingerprinting analyses, were determined. Then, skin-related antimicrobial, antioxidant, and antiaging activities were determined. The results revealed that MPR showed the highest L-DOPA content (75.94 mg/100 mg extract), whereas MGG exhibited the highest phenolic and flavonoid content (56.73 ± 0.62 mg gallic/g extract and 1030.11 ± 3.97 mg quercetin/g extract, respectively). Only MMM and MPR could inhibit all of S. aureus, S. epidermidis, and C. albicans, but no sample could inhibit C. acnes. Furthermore, all samples demonstrated antioxidant activity. Interestingly, all Mucuna samples exhibited strong collagenase, elastase, and hyaluronidase inhibitory activities. We conclude that the ethanolic extracts of four Mucuna seeds are probably advantageous in the development of skincare cosmeceutical products.
Highlights
Introduction published maps and institutional affilThe genus Mucuna, belonging to the Fabaceae family, is composed of approximately115 species globally distributed in pantropical regions [1]
Considering the best max score and percent identity, the results revealed that M. gigantea (Willd.) DC. (MGG), M. interrupta Gagnep. (MIT), M. monosperma Wight (MMM), and M. pruriens (MPR) originated from M
The results showed that MGG possessed the highest lipid-peroxidation property (IC50 at 4.44 mg/mL) compared with other Mucuna extracts (p < 0.05)
Summary
Introduction published maps and institutional affilThe genus Mucuna, belonging to the Fabaceae family, is composed of approximately115 species globally distributed in pantropical regions [1]. The genus Mucuna, belonging to the Fabaceae family, is composed of approximately. There are 14 taxa found in Thailand, including Mucuna bracteata DC., M. pruriens (L.) DC., M. gigantea (Willd.) DC., M. macrocarpa Wall., M. interrupta Gagnep., M. warburgii K. (Figure 1) [2,3] The members of this genus have been used in various fields, namely agriculture and foods, including medicines. M. bracteata has been cultivated as green manure in the plantations of economic crops, such as maize, cotton, and rubber tree [4,5]. M. pruriens, an important species in this genus, has been utilized as a food source since its seeds contain a high protein content, around 25% [6]. Populations, in some areas, consume both the green pods and the mature beans of M. pruriens by cooking or boiling them
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