Abstract
Six different extracts of Melodinus eugeniifolus (a very rare medical plant belonging to Apocynaceae) leaves and barks were screened for their phytochemical composition, and free radical scavenging activities. Three different methods were used to test the antioxidant activity for extracts which include FRAP assay (Ferric reducing antioxidant potential), DPPH radical scavenging assay (1,1-diphenyl-2-picryl hydrazyl radical reducing power methods), and β-carotene bleaching assay. Among the different extracts tested, the ethanol extract of barks showed significant radical scavenging activities. Phytochemical analysis of the extracts revealed that the radical scavenging activities are mainly due to the presence of alkaloids, cardiac glycosides, sterols, steroids and flavonoids. The results obtained suggest that Melodinus eugeniifolus could be exploited in the management of various diseases like cancer, cardiovascular diseases and infection diseases. Highlights: Melodinus eugeniifolus, a very rare medical plant from South Asian rain forest which may be a potential drug for many diseases is first reported about its phytochemical characteristics and antioxidant activity by different methods.
Highlights
The term “antioxidant” refers to any substance that delays, prevents or removes oxidative damage to a target molecule [1]
Within the past decade, a considerable body of evidence has accumulated in support of the view that natural products with antioxidant properties might be beneficial to health and several in vitro antioxidant techniques have been developed such as FRAP, DPPH and β-carotene bleaching assay
One ought to perform several methods to accurately estimate the antioxidant potential of a sample as it should cover the mechanisms of different reactions [4]
Summary
The term “antioxidant” refers to any substance that delays, prevents or removes oxidative damage to a target molecule [1]. One ought to perform several methods to accurately estimate the antioxidant potential of a sample as it should cover the mechanisms of different reactions [4]. A very rare medicinal plant belongs to the family of Apocynaceae. This family consists of 424 genera and 1500 species of trees. As part of an ongoing study to identify antioxidants from medicinal plants, we have previously extracted hexane, chloroform and ethanol. With this premise in mind we seek to examine the antioxidant potencies and principle of the Malaysian medicinal tree Melodinus eugeniifolus
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