Abstract
Antiplasmodial and antioxidant activities of extracts derived from Trichilia roka (Chiov) root bark and Sapium ellipticum (Hochst) Pax root bark were determined respectively in vivo by Peters et al. methods and by DPPH radical-scavenging and β-carotene-linoleate model systems. Of those extracts, the two methanolic extracts revealed a good antioxidant and the antiplasmodial activities. The T. roka methanolic extract was more effective than S. ellipticum extract concerning antiplasmodial activity and the S. ellipticum extract, the most promising one concerning antioxidant activity with IC50 42.18 μg/ml better than BHT value IC50 83.36 μg/ml taking as control. The high activities of these two plant extracts suggest that they are good source of natural antioxidant and may contain new compounds with lead structures for drug development against malaria.
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