Abstract
My life with progesteroneAmerican Journal of Obstetrics & GynecologyVol. 193Issue 4PreviewThe twists and turns of fate have linked my name so many times with the other ovarian hormone that I still shudder when some senior citizen says, “You must have been awfully young when you worked with Doisy.” The confusion arises because there are 2 Allens whose names have become attached to the 2 ovarian hormones. Edgar Allen (1892-1943) and Edward Adelbert Doisy (1893-1986) announced their discovery of a hormone in the ovarian follicular fluid in 1923.1 George Washington Corner (1889-1981) and I announced the discovery of a second ovarian hormone in the corpus luteum in 1929. Full-Text PDF Comment by Lawrence D. Longo, MDAmerican Journal of Obstetrics & GynecologyVol. 193Issue 4PreviewGeorge Washington Corner (1889-1981) and Willard Myron Allen (1904-1993) (the latter a medical student at the time) first obtained a secretory endometrium in the rabbit uterus after injection of an extract of corpus luteum, which laid the groundwork for the isolation of progesterone. Illustrated above, several figures are from a nonpregnant rabbit uterus after an ophorectomy and various treatments: 1 and 5, Normal control from mature rabbit; 7, control from immature rabbit; 2, proliferative endometrium in response to 5 days treatment with corpus luteum extract; 3, same after a larger dose; 8, same in immature animal; 4, same after one-half minimal effective dose; 6, treatment with follicular fluid (presumably containing estrogen); 9, same in immature animal. Full-Text PDF
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