Abstract
The pancreatic physiology is examined on the basis of recent advances observed these past ten years. A new model for pancreatic duct cell bicarbonate secretion is proposed according to the recently discovered Cystic Fibrosis Transmembrane conductance Regulator mutated in cystic fibrosis. Enzyme activation and inactivation are detailed allowing comprehensive pancreatic secretory function and relationships between trypsinogen and the occurrence of hereditary pancreatitis. Previously, pancreatic secretion was thought to be exclusively controlled by neural reflex mechanisms. Later, it has been proposed to be predominantly regulated by gastrointestinal hormones, with CCK and secretin being the most important regulatory peptides. New data from the research on the localization and role of gastrointestinal peptide receptors in the human pancreas support the current concept of an integrative neurohormonal regulation.
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