Abstract
Tobacco scions were grafted onto tomato stocks to provide tobacco leaves essentially free of pyridyl alkaloids. These leaves were used for testing the intermediary role of nicotine-1 -oxide in the conversion of nicotine to nornicotine. Nicotine-1'-oxide was neither converted to nornicotine, nor did it inhibit the conversion of nicotine. These findings eliminate nicotine-1'-oxide from consideration as an intermediate. Preliminary evidence indicating that N'-formyl nornicotine does not play a significant role in the conversion has also been obtained.
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