Physiological And Histological Toxic Effects Of Different Doses Of Nandrolone Decanoate On The Kidney Of Male Mice

Abstract

Anabolic androgen steroids are widely used among athletes to increase muscles mass. Some patients with chronic kidney disease are also used these drugs. But the effect of these drugs on the kidney structure receives less attention.The current study was performed to investigate the histopathological effects of nandrolone decanoate injection in kidney tissues of adult male mice. Thirty adult male mice (balb / c) were randomly divided into three groups (10 mice in each group): two groups treated were injected subcutenously in the distled region of femur with 50 and 100 mg / kg b.w of Nandrolone Decanoate every 2 days for 4 weeks , while the control group was injected with 0.9% normal sline solution. Two physiological parameters were performed including urea and creatinine levels. The results showed that there was a significant increase (P