Abstract
Methylphosphonate (MP)-substituted antisense DNA oligomers have significant potential for genome targeted therapy. The physicochemical basis of the difference in R-versus S-MP diastereomers incorporated into DNA oligomers with regard to complementary DNA target hybridization has been poorly understood. State of the art advanced molecular computational methods and supercomputer technology were applied to identify key physicochemical determinants involved in stabilizing and destabilizing target hybridization
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