Abstract
Proteins have complicated three-dimensional structures with multilevel conformations, which can be altered to different extents on interactions with foreign molecules or nanoparticles. Soft protein like bovine serum albumin (BSA) is the most extensively studied proteins, as on surface adsorption BSA generally undergoes conformational reorientation unlike a hard protein lysozyme. BSA whose structure is similar to that of human serum albumin (HSA) is considered to be a model protein. In fact, study of BSA can be considered to be a key step before moving to its human version. Understanding the interaction of these proteins with nanomaterials becomes extremely important for utilizing them in biomedical applications especially in drug delivery and even disease diagnosis. Different types of surface functionalization are being tried on nanoparticle for improving their physicochemical properties. Keeping all these view in mind, this Study was designed to understand the physicochemical properties of 3-aminopropyl triethoxy silane (APTS) coated ZnFe 2 O 4 nanoparticles upon their interaction with BSA using UV-visible spectroscopy, circular dichroism (CD) spectroscopy and CD melting studies.
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