Physicochemical characterization and solubility enhancement studies of Felodipin solid dispersions

Abstract

The aim of present work is to develope fast dissolving tablets of Felodipine by first preparing solid dispersion with PEG 6000 and PVP K30 in ratio 1:1, 1:3 by direct compression method using different superdisintegrant such as crospovidone (CP), croscarmellose sodium (CCS). The prepared tablets were evaluated for pre-compression parameters such as angle of repose, bulk density, compressibility index, hausners ratio and post-compression parameters such as thickness, hardness, friability, drug content, weight variation, wetting time, water absorption ratio, In-Vitro disintegration time, in-vitro dissolution studies and stability studies. All the parameters showed good results. The study reveals that formulations prepared by direct compression F5 exhibits highest dissolution using croscarmellose sodium & showed faster drug release 99.89% over the period of 21 min. F5 batch disintigrate in 55 sec.show good disintegration comparison to other formulations of Felodipine.