Abstract
The objective of the work is physicochemical characterization of meloxicam (ME)–cyclodextrin (CD) binary systems both in solution and solid states and to improve the dissolution properties of meloxicam via complexation with α-, β- and γ-cyclodextrins. Detection of inclusion complexation was done in solution state by means of phase solubility analysis, mass spectrometry and 1 H nuclear magnetic resonance (NMR) studies, and in solid state using differential scanning calorimetry (DSC), powder X-ray diffractometry, and in vitro dissolution studies. Phase solubility, mass spectrometry and 1 H NMR studies in solution state revealed 1:1 M complexation of meloxicam with all CDs. A true inclusion of ME with γ-CD at 1:1 and 1:2 M in solid state was confirmed by DSC, powder XRD and scanning electron microscopy (SEM) studies. Dissolution properties of ME–CDs binary systems were superior when compared to pure ME.
Published Version
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