Physico-chemical and biological properties of novel Eu-doped carbonization modified tricalcium silicate composite bone cement

Abstract

This paper introduces a novel composite bone cement (Eu:HAp/V-C3S), which is composed of carbonated tricalcium silicate (V-C3S) and europium-doped hydroxyapatite (Eu:HAp), and Eu:HAp was generated by hydrothermal synthesis. The physical and chemical properties, mineralization in vitro, biocompatibility and bacteriostasis of the composite bone cement were evaluated. The results show that the Eu:HAp/V-C3S composite bone cement has good setting properties and a relatively low pH value. The composite bone cement with 0.1 wt% Eu has a higher compressive strength than pure V-C3S (141.06% higher than pure V-C3S), which can greatly improve the mechanical properties of the materials. The in vitro immersion test shows that composite bone cement has good mineralization ability. The cell test proves that it has good cell proliferation ability and low cytotoxicity. In addition, the bacteriostatic experiment also verifies that composite bone cement has bacteriostatic effect to some degree. These results indicate that Eu:HAp/V-C3S composite bone cement is a promising biomedical material.