Abstract
The thermal and structural properties of nitrazepam and citric acid have been studied alone and in the corresponding binary mixture, using differential scanning calorimetry (DSC), Fourier Transform Infrared spectroscopy (FTIR), and X-ray diffraction (XRD). The thermodynamic study of the binary mixture nitrazepam-citric acid was made by DSC analysis. The mixtures were obtained by mechanosynthesis. For the binary mixtures, an eutectic reaction was observed in all DSC curves at 396 K. The phase diagram and Tamman's plot suggest an eutectic composition at the ≈0.4 molar fraction of nitrazepam. XRD and FTIR have been used as complementary methods to demonstrate that the obtained compound is eutectic. The solubility tests have been performed on the eutectic composition and nitrazepam. The results showed that the parameter influencing the solubility of nitrazepam is the acidic character of the sample.
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