Abstract
Epilepsy is a chronic and the fourth most common neurological disorder which affects people of all age groups. Recently research and awareness on epilepsy-related deaths have rapidly grown over the past two decades. Many previous studies are attributed to the guidelines that apprise health care professionals in handling these deaths, but there is a relative scarcity of information accessible for clinicians and pharmacists who are responsible for manufacturing or preparing the extemporaneous anti-epileptic suspensions in the hospitals. Mostly in partial seizures, phenytoin is one of the first-choice drugs. In Saudi Arabian hospitals, the extemporaneous preparation of phenytoin suspension is common, but the hot climatic weather in Saudi Arabia possesses stability problems that should be tackled as the prepared suspension should pass all the stability tests to ensure uniform dosage of the extemporaneous formulation. In the current study, the commercial capsules were used to prepare the oral phenytoin sodium extemporaneous suspension. The physical, chemical and microbiological stability of phenytoin sodium suspension is analyzed at various temperatures.
Highlights
IntroductionNon-contagious disease of the brain which affects people of all ages
Epilepsy is a chronic, non-contagious disease of the brain which affects people of all ages
In Saudi Arabian hospitals, the extemporaneous preparation of phenytoin suspension is common, but the hot climatic weather in Saudi Arabia possesses stability problems that should be tackled as the prepared suspension should pass all the stability tests to ensure uniform dosage of the extemporaneous formulation
Summary
Non-contagious disease of the brain which affects people of all ages. As stated by a World health organization (WHO) analysis, worldwide 50 million people suffer from epilepsy, making it one of the most common neurological disorders [1]. It is a noncommunicable chronic disease of the brain where electrical imbalances occur. Phenytoin is an efficacious anti-epileptic drug that is used to prevent focal and tonic-clonic seizures (grand mal seizure) [2]. It is commercially sold in both solid and liquid dosage form as a chewable tablet, extended-release capsule and oral suspension as well. The stability of such formulations is crucial [4]
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