Abstract
The influence of excipients and lubricants on the chemical and physical stability of tablets is demonstrated. Tablet color stability and its measurement is reviewed. The applicability of chemical kinetic principles and the Arrhenius relationship to stability data for tablet systems is illustrated. The importance of the package to product stability is shown. The utility of exaggerated temperature, light, and humidity conditions in the stability testing of tablet dosage forms is demonstrated. The importance and significance of a well-organized stability testing program for evaluating the physical and chemical stability of solid dosage forms are discussed.
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