Physical activity, grape juice, red wine and resveratrol effects in cardiac remodeling of Wistar rats submitted to a high fat diet

Abstract

Background: The association between regular physical activity and the polyphenol-rich drinks in models with a high fat diet, has not been sufficiently elucidated. Objective: The objective was to study the effects of the association among regular physical activity and polyphenol-rich drinks consumption in lipid profile and cardiac remodeling of Wistar rats submitted to the high fat diet. Methods: Rats Wistar, 90 days, 05 groups (n=10/group): Control Group (CG); High Fat Group (HG); Resveratrol Group (RG); Grape Juice Group (JG); Red Wine Group (WG); HG, RG, JG and WG received a high fat diet (20%). The animals performed a treadmill running protocol for 60 days. After, blood was collected for biochemical evaluation and heart was removed for histological analysis. Variables were expressed as mean ± standard deviation. ANOVA one way and Bonferroni or Tuckey`s as post-test, when appropriate, p < 0.05. Results: JG show higher total cholesterol (72.0 ±8.9 p<0.05) and HDL (28.0 ± 2.0 p<0.05) in relation to CG (total cholesterol = 57.8 ± 8.1, HDL = 24.4 ± 2.9). Collagen concentration: HG (9.65%, p<0.05) presented higher concentration in relation to the CG (3.68%), RG (4.73%), JG (3.57%) and WG (6.59%). Conclusions: It is concluded that the association between physical activity and drinks rich in polyphenols was able to protect the heart tissue from damage caused by the high fat diet.