Physical Activity and the Missing Calories.

Abstract

The obesity epidemic is thought widely to result from sustained high food intake combined with limited physical activity, which is further exacerbated by our maladaptation to these conditions. According to geneticist James Neel’s “Thrifty Gene Hypothesis,” the human genome evolved “thrifty genes” via natural selection to help individuals fatten more quickly during periods of feasting and survive better during times of famine or when exposed to predators (2,6). Although the thrifty genotype conferred a survival advantage to our hunter-gatherer ancestors, these genes are detrimental in our modern society where food is abundant perpetually and there are fewer demands for physical activity. This evolutionary hypothesis is endorsed widely as a plausible explanation for the high prevalence of obesity and Type 2 diabetes in modern society. In this issue of the Journal, Pontzer (3) proposes a similar evolutionary hypothesis that natural selection has shaped our physiology to conserve energy. He begins by stating that scientists typically assume energy expenditure to be additive (factorial); total daily energy expenditure is the sum of resting metabolic rate (energy necessary for maintenance and repair), the thermic effect of feeding (energy needed to digest, absorb, and store the ingested food), and the energy cost of structured and spontaneous physical activity. According to the additive model, an increase in physical activity always increases energy expenditure. In contrast to the additive model, Pontzer postulates that daily total energy expenditure is rather stable, despite rather large changes in physical activity. Invoking evolutionary principles, Pontzer proposes a “constrained energy expenditure” model, where energy balance is regulated homeostatically. In Pontzer’s model, total daily energy expenditure (adjusted for body weight) does not increase in proportion to physical activity but instead is constrained within a rather surprising narrow range that favors evolutionary survival. In support of this model, Pontzer presents data from both humans and many animal species showing that total daily energy expenditure is not influenced much by physical activity. Pontzer then provides ecological reasons why high levels of physical activity do not alter energy balance as much as expected, thus explaining why physical activity often has little impact on weight loss strategies. Although it is known that extra calories burned through exercise often do not translate into weight loss, the lack of exercise efficacy — those “missing calories” — has been attributed to compensation through increased food intake. However, Pontzer argues that the missing calories can be explained by a decrease in nonactivity energy expenditure, particularly resting energy expenditure, rather than an increase in food intake. In support of this constrained energy expenditure model, Pontzer cites evidence of no difference in energy expenditure between wild and captive primates. He also compares populations in different settings in which they have high food availability with low physical activity (Westernized societies) versus high physical activity with limited food availability, such as in the Hadza, a modern-day hunter-gatherer population in Africa. However, there are compelling data from humans showing that energy intake is indeed increased in response to exercise (e.g., (1)). Unfortunately, the evidence presented by Pontzer does not include data on energy balance, and it is possible that these constraints on energy expenditure only operate under certain conditions of ill-favored negative energy balance. Another possibility is that energy expenditure does not increase with structured physical activity because of decreases in spontaneous physical activity (e.g., fidgeting) or reductions in the energy cost of physical activity (e.g., improved muscle efficiency) rather than from reductions in resting metabolic rate. Indeed, spontaneous physical activity can account for a large amount of caloric expenditure even in sedentary conditions and may represent a buffer against changes in structured physical activity (5). Moreover, as Pontzer admits, athletes and subsistence farmers present a clear challenge to his model because they exceed the proposed limits on energy expenditure, even after correcting for body size (3). And even in the case of the Hadza who have comparable energy expenditure to Westerners once adjusted for fat-free mass, the Hadza expend more energy in physical activity and are leaner than their Western counterparts (4). Therefore, despite a possible upper limit on energy expenditure, physical activity can reduce adiposity. Despite some limitations with his model, Pontzer makes an important contribution to show convincingly that increases in physical activity often do not translate into increases in total energy expenditure. Moreover, he demonstrates that models of energy expenditure and physical activity must accommodate both evolutionary and ecologic pressures in the context of maintaining energy balance. Eric Ravussin Courtney M. Peterson Skeletal Muscle Physiology Lab Pennington Biomedical Research Center Baton Rouge, LA C. Peterson is supported in part by 1 U54 GM104940 from the National Institute of General Medical Sciences of the National Institutes of Health, which funds the Louisiana Clinical and Translational Science Center. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.