Abstract
A comparative study of common core secondary structure in the ribosomal internal transcriber 2 (ITS2) and cyotchrome oxidase subunit I (COI) of 11 and 5 isolates respectively were selected from different hosts was carried out. Sarcoptes cause scabies of different nature in different hosts. Multiple sequence alignment and secondary structural analysis of ITS2 and COI was performed to elucidate the phylogenyetic relationships. This study reveals a phylogenetic relationship among the different isolates of sarcoptes form different hosts. Several common features of secondary structures are shared among these isolates, with some of them support by compensatory changes, suggesting the significant role by ITS2 and COI as an RNA domain during ribosome biogenesis. The study also shows ITS2 in combination with COI sequence analysis gives a better understanding of intra generic variation in sarcoptes.
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