Phthalimido protected peptide nucleic acid monomer – Synthesis and Characterization

Abstract

Glycine based peptide nucleic acid (PNA) monomers are useful in the construction of PNA oligomers which are, in general, hydrophobic in nature. To overcome this huddle, serine based peptide nucleic acid (PNA) monomer was synthesized which will a good candidate in terms of increasing hydrophilicity. The synthesis involves in the alkylation of N-bromoethyl phthalimide on nosyl protected serine methyl ester followed by deprotection and condensation with nucleobase yields PNA monomer. The phthalimide group on nitrogen serves as protecting group as well as marker.