Abstract
Four new dimeric phthalides, angesinenolides C−F (1−4), along with three known ones, were isolated from the roots of Angelica sinensis. Their structures were determined by means of HRMS and NMR experiments. The structures of compounds 1 and 3 were confirmed using X-ray crystallographic data. All isolated compounds were tested for activities on the inhibition of COX-2 enzyme in vitro. Compounds 1–6 exhibited inhibitory activity against COX-2 with IC50 values ranging from 29.32 ± 0.07 to 137.91 ± 0.24 μM.
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