PHP121 - EVALUATION OF ADVERSE DRUG REACTIONS IN A HOSPITAL IN SOUTHERN TAIWAN

Abstract

According to the definition of adverse drug reaction (ADR): “An appreciably harmful or unpleasant reaction, resulting from an intervention related to the use of a medicinal product, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the produtct.” Data collection and analysis from our hospital, which can provide healthcare professionals as a reference in clinical practice. This study is a retrospective investigation of ADRs enrolled in our hospital in southern Taiwan in 2015. Assessment of ADRs contains that occurring sources, gender and age, Anatomical Therapeutic Chemical (ATC) classification of suspected drugs, types of adverse reactions, Naranjo score calculating by Naranjo Adverse Drug Reaction Probability Scale, and so on. The study included one hundred and eight ADRs. Most of ADRs were occurring in outpatient department (94%). The average age of ADRs was 65.2 years. Less than 65 years of age were in the majority in this study (58%). Majority of all were females (54%). On the basis of ATC classification system, the major categories of suspected drugs were Cardiovascular system (19%). The major type of adverse reactions was Dermatologic Effects (35%). Besides, the major Naranjo scores of all ADRs ranged from 1 to 4 points (98%), a possible correlation between ADRs and suspected drugs. To date the safe use of medicines is still a critical issue for healthcare professionals and the public. The purpose of ADRs reporting, not only to prevent from delivering the same or similar medicines to patients, but also to improve the safety of medication use. Prescribers aim to use medicines that aid patients and do no harm, but no drugs is administered without risk. Therefore, healthcare professionals have a responsibility to their patients, who themselves are becoming more aware of problems associated with drug therapy.