Abstract
Photosensitizer-free vaccination strategy can be accompanied by delivery of nanoadjuvants. B16F10 melanoma cells show a photothermal effect under irradiation of near-infrared light. The nanoadjuvant, with imiquimod in amphiphilic peptide-based micelles, induces dendritic cell maturation. Near-infrared-irradiated and nanoadjuvant-treated group prevents lung metastasis of B16F10. Photosensitizer-free phototherapy with a peptide micelle nanoadjuvant has potential for clinical translation as a melanoma vaccine. This is reported by Gayong Shim, Yu-Kyoung Oh, and co-workes in article number 2000288.
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