Photorefractive keratectomy combined with corneal wavefront–guided and hyperaspheric ablation profiles to correct myopia

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To evaluate the effects of photorefractive keratectomy (PRK) combined with corneal wavefront-guided ablation profiles and hyperaspheric ablation profiles on changes in higher-order aberrations (HOAs). Yonsei University College of Medicine and Eyereum Clinic, Seoul, South Korea. Comparative observational case series. Medical records of patients who had corneal wavefront-guided hyperaspheric PRK, corneal wavefront-guided mild-aspheric PRK, or non-corneal wavefront-guided mild-aspheric PRK were analyzed. The logMAR uncorrected distance visual acuity (UDVA), manifest refraction spherical equivalent (MRSE), and changes in corneal aberrations (root-mean-square [RMS] HOAs, spherical aberration, coma) were evaluated 1, 3, and 6months postoperatively. The records of 61 patients (96 eyes) were reviewed. There was no statistically significant difference in logMAR UDVA or MRSE between the 3 groups at any timepoint. Corneal RMS HOAs were significantly smaller in the corneal wavefront-guided hyperaspheric group and the corneal wavefront-guided mild-aspheric group than in the noncorneal wavefront-guided mild-aspheric group at each timepoint. Corneal spherical aberration was significantly smaller for corneal wavefront-guided hyperaspheric PRK than for noncorneal wavefront-guided mild-aspheric PRK 6months postoperatively. Changes in corneal spherical aberration (preoperatively and 6months postoperatively) in corneal wavefront-guided hyperaspheric PRK were significantly smaller than in corneal wavefront-guided mild-aspheric PRK (P=.046). Corneal coma was significantly smaller with corneal wavefront-guided hyperaspheric PRK and corneal wavefront-guided mild-aspheric PRK than with noncorneal wavefront-guided mild-aspheric PRK 3months and 6months postoperatively. Corneal wavefront-guided hyperaspheric PRK induced less corneal spherical aberration 6months postoperatively than corneal wavefront-guided mild-aspheric PRK and noncorneal wavefront-guided mild-aspheric PRK. None of the authors has a financial or proprietary interest in any material or method mentioned.