Photoredox‐Mediated Minisci Alkylation of N‐Heteroarenes using Carboxylic Acids and Hypervalent Iodine

Abstract

AbstractA new protocol of photoredox‐mediated Minisci alkylation of N‐heteroarenes with aliphatic carboxylic acids has been developed. Using Ru(bpy)3Cl2 as photocatalyst and acetoxybenziodoxole (BI–OAc) as oxidant, a variety of primary, secondary and tertiary alkyl groups can be efficiently incorporated into various electron‐deficient N‐heteroarenes. This protocol demonstrated excellent substrate scope and good functional group tolerance and can be applied to late‐stage functionalization of complex molecules.