Abstract
A new non-conjugated corrole-coumarin dyad and its gallium complex has been synthesized. Photophysical properties of the dyads were tested in two solvents, exhibiting strong solvent effect on the absorption and fluorescence spectra. Absorption spectra of the dyads are a linear combination of the spectra of their corresponding monomers, demonstrating a negligible electronic communication between coumarin and corrole moiety. However, fluorescence emission of coumarin entity in all dyads were quenched significantly as compared to pristine coumarin; this was attributed to intramolecular energy transfer from coumarin to the corrole. Photodynamic anti-tumor tests revealed that gallium corrole-coumarin dyads (2-Ga) exhibited good PDT activity towards SiHa cells. After PDT treatment, 2-Ga could induce apoptosis in SiHa cells, which was associated to cell S phase arrest, collapse of the mitochondrial membrane potential and increase of the intracellular ROS level.
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