Photoperiodic regulation of puberty in seasonal species

Abstract

Puberty occurs seasonally in the majority of mammals native to temperate or arctic latitudes, and in species with sufficiently long life spans puberty can be considered to reoccur on an annual basis. The precise timing of puberty and the annual reoccurrence of fertility reflects an interaction of changes in ambient daylength (photoperiod) and endogenous long-term timing processes, which in some species constitute circannual clocks. Recent studies reveal an unexpected common signalling pathway for photoperiodic information in mammals and birds: changes in secretory activity of the pars tuberalis in the pituitary stalk signal to the tanycyte cells in the ependyma lining the third ventricle. The target genes in the tanycytes encode the deiodinase enzymes that regulate the availability of thyroid hormone in the hypothalamus. Central availability of thyroid hormone appears to be the key determinant of seasonal reproductive transitions. Given the necessity of thyroid hormone for the initial development of the central nervous system, it is hypothesized that at puberty and seasonal reoccurrences of fertility it is the changing local levels of thyroid hormone that orchestrate hypothalamic plasticity, ultimately impinging upon the secretion of GnRH.