Photodynamic therapy in combination with photothrombosis therapy of atherosclerotic plaques with neovessels, using rose bengal and polarized green laser

Abstract

Background and Aims : Atherosclerotic lesions are considered to be advanced when the accumulation of lipid, immune cells, and matrix is associated with the disorganization, thickening and deformity of the arterial wall. One of the most vulnerable type of advanced atherosclerotic plaques, is neovessels- rich plaque. In this study, we investigated the effectiveness of combined photodynamic therapy and photothrombosis therapy on the intraplaque neovessels reduction, wherein a high resolution diagnostic ultrasound is adjuncted with the therapy system, with a goal of increased safety.