PHOTODYNAMIC THERAPY FOR CERVICAL CANCER:
 A LITERATURE REVIEW

Abstract

Relevance: Cervical cancer is a major public health problem worldwide, with human papillomavirus infection playing a vital role as a risk
 factor. Photodynamic therapy is a minimally invasive treatment for HPV-related cervical lesions that uses photosensitizers and light to selectively
 destroy abnormal cells.
 The study aims to comprehensively review the different types of molecules used in PDT to reduce the morbidity and mortality associated with
 cervical cancer.
 Methods: A comprehensive search was conducted for all relevant articles investigating the efficacy and safety of PDT in the treatment of
 HPV-associated cervical cancer. PICO scores were determined for the review, and a literature search of the PubMed database was performed. An
 examination of the PubMed online database using keyword combinations identified 71 studies conducted between 2013 and 2023 that investigated
 using PDT to treat RSM cells.
 This article reviews ongoing clinical trials examining the efficacy of PDT in treating low-grade squamous cell intraepithelial neoplasia and
 high-grade squamous cell intraepithelial lesions, as well as preclinical approaches using different molecules for PDT in cervical cancer.
 Results: Potential molecules for PDT are described, their advantages and disadvantages evaluated, and solutions to improve their compatibility with antitumor treatment are proposed. Our review shows that PDT is a promising therapeutic approach for diagnosing and treating HPV-related
 cervical lesions. At the same time, we observe that using different classes of dyes enhances the anticancer effects of PDT.
 Conclusion: Fullerene and ALA-PDT are potential leaders for more intensive use in PDT, which will further help reduce the global incidence
 and mortality from cervical cancer. However, further studies are needed to evaluate its long-term efficacy and safety.