Abstract
AbstractHydrogels are attractive materials for generating 4D shapes due to their ability to undergo pronounced volume changes in response to several stimuli, including light. We previously reported shape‐changing hydrogels actuated by long‐wave UV and visible light in the presence of live cells using poly(ethylene glycol) macromers incorporating different photodegradable ortho‐nitrobenzyl (o‐NB) groups. In this comprehensive study, we determine the effect of chemical structure of different o‐NB macromers (which influences molar absorptivity and rate constant of degradation), composition (macromer weight percent), fabrication design (initial gel thickness) and environment (ionic strength of solution) on light‐induced hydrogel folding. We demonstrate successful photopolymerization and subsequent photodegradation of hydrogels, multistep folding, and live‐cell encapsulation. This hydrogel system may be useful as new tool in stem cell differentiation and developmental biology research, facilitating the in vitro investigation of processes that are sensitive to both physical and temporal stimuli.
Published Version
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