Photo-Cured Glycol Chitosan Hydrogel for Ovarian Cancer Drug Delivery.

Hoon Hyun,Dae Yang,Min Park,Heung Chun,Gayoung Jo,So Kim

doi:10.3390/md17010041

Hoon Hyun, Dae Yang + Show 4 more

Open Access

https://doi.org/10.3390/md17010041

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Abstract

In this study, we prepared an injectable drug delivery depot system based on a visible light-cured glycol chitosan (GC) hydrogel containing paclitaxel (PTX)-complexed beta-cyclodextrin (β-CD) (GC/CD/PTX) for ovarian cancer (OC) therapy using a tumor-bearing mouse model. The hydrogel depot system had a 23.8 Pa of storage modulus at 100 rad/s after visible light irradiation for 10 s. In addition, GC was swollen as a function of time. However, GC had no degradation with the time change. Eventually, the swollen GC matrix affected the releases of PTX and CD/PTX. GC/PTX and GC/CD/PTX exhibited a controlled release of PTX for 7 days. In addition, GC/CD/PTX had a rapid PTX release for 7 days due to improved water solubility of PTX through CD/PTX complex. In vitro cell viability tests showed that GC/CD/PTX had a lower cell viability percentage than the free PTX solution and GC/PTX. Additionally, GC/CD/PTX resulted in a superior antitumor effect against OC. Consequently, we suggest that the GC/CD system might have clinical potential for OC therapy by improving the water solubility of PTX, as PTX is included into the cavity of β-CD.

Highlights

Paclitaxel (PTX) is one of the most widely used anticancer drugs for epithelial ovarian cancer (OC) chemotherapy [1]
The results showed that glycol chitosan (GC), GC/PTX and GC/CD and PTX (CD/PTX) had degradationfor rates of less than for 7 days, indicating almost no degradation
The results showed that GC, GC/PTX and degradation rates of less than 1% for 7 days, indicating almost no degradation

Summary

Introduction

Paclitaxel (PTX) is one of the most widely used anticancer drugs for epithelial ovarian cancer (OC) chemotherapy [1]. It induces apoptosis in cancer cells by targeting microtubules involved in mitotic spindle formation during cell division, the maintenance of cell structure and motility, and cytoplasmic movement [2]. Chemotherapy for OC has been changed to a combination of platinum and taxane drugs from single anticancer drugs via intravenous and intraperitoneal administrations [3]. For PTX, its limited water solubility causes poor bioavailability. Water-soluble PTX systems, such as TAXOL® and Genexol® PM Injection, have been clinically applied to treat cancers, but they still

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