Abstract
Scarless wound healing is ideal for patients suffering from soft tissue defects. In this study, we prepared a novel wet dressing (β-CD-ic-CUR/GC) based on the visible light-cured glycol chitosan (GC) hydrogel and inclusion complex between beta-cyclodextrin (β-CD) and curcumin (CUR). We also evaluated its efficacy in the acceleration of wound healing as compared to that of CUR-loaded GC (CUR/GC). The conjugation of glycidyl methacrylate (GM) to GC for photo-curing was confirmed by 1H-NMR measurement, and the photo-cured GC hydrogel was characterized by the analyses of rheology, swelling ratio, SEM and degradation rate. After visible light irradiation, the surface/cross-sectional morphologies and storage (G′)/loss (G′′) moduli revealed the formation of hydrogel with interconnected porosity. The dressing β-CD-ic-CUR/GC exhibited a controlled release of 90% CUR in a sustained manner for 30 days. On the other hand, CUR/GC showed CUR release of 16%. β-CD acted as an excipient in improving the water-solubility of CUR and affected the release behavior of CUR. The in vivo animal tests including measurement of the remaining unhealed wound area and histological analyses showed that β-CD-ic-CUR/GC may have potential as a wet dressing agent to enhance soft tissue recovery in open fractures.
Highlights
Wound dressings have been extensively developed for reducing pain, protecting the wound and surrounding tissue, and promoting the moist wound environment that exists in various wounds cause by excision, burns, trauma or orthopedic surgery [1]
Conjugation of glycidyl methacrylate (GM) to glycol chitosan (GC) was confirmed by 1 H-NMR measurement
The results demonstrated that GM was successfully at 1.75, 1.95 and 3.24–3.96 ppm were observed for GC
Summary
Wound dressings have been extensively developed for reducing pain, protecting the wound and surrounding tissue, and promoting the moist wound environment that exists in various wounds cause by excision, burns, trauma or orthopedic surgery [1]. UV light may wetthe wound the hydrogel form is designed to hold moisture at the surface, providing an ideal melanoma environment by for DNA wounddamage cleansingowing and autolytic the radicals cause sunburn, and malignant to the debridement, formation ofbyfree surgical stress, exposure of the whole damage pathological zone and the removal of allopen necrotic, contaminated and oxidative and further of injury soft tissue associated with fractures [6]. The incorporation of drugs or growth factors in hydrogels merit of chitosan, it has limited clinical use because of its low bioavailability due to poor water has been solubility [10]. Can be synthetic drugs or growth factors, as a natural extract, curcumin (CUR) has no toxicity and has aused as a half-life, it is known toofaccelerate healing owing to its antioxidant, antitool for longer improving theand water-solubility. Confirmed by measuring the remaining wound area and histological observation of the hydrogeltreated wound defects
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
