Abstract
A two-stage polylactide modification was performed in the supercritical carbon dioxide medium using the urethane formation reaction. The modification resulted in the synthesis of polymerizable methacrylate derivatives of polylactide for application in the spatial 3D structuring by laser stereolithography. The use of the supercritical carbon dioxide medium allowed us to obtain for the first time polymerizable oligomer-polymer systems in the form of dry powders convenient for further application in the preparation of polymer compositions for photocuring. The photocuring of the modified polymers was performed by laser stereolithography and two-photon crosslinking. Using nanoindentation, we found that Young’s modulus of the cured compositions corresponded to the standard characteristics of implants applied in regenerative medicine. As shown by thermogravimetric analysis, the degree of crosslinking and, hence, the local stiffness of scaffolds were determined by the amount of the crosslinking agent and the photocuring regime. No cytotoxicity was observed for the structures.
Highlights
Polymeric biocompatible materials have been in special demand in the new field of medical materials science, tissue engineering, associated with reconstructive surgery and the development of artificial organs [1]
The single-stage synthesis is the simplest way of modification; the lower reactivity of poly(lactic) acid acid (PLA) terminal hydroxyl groups with respect to the EGM
To boost the degree of modification of the methacrylate polylactide derivative, we used a molar excess of ITI and EGM with respect to PLA
Summary
Polymeric biocompatible materials have been in special demand in the new field of medical materials science, tissue engineering, associated with reconstructive surgery and the development of artificial organs [1]. To design a new generation of implants applied in the replacement of lostdamaged or damaged and one organs, needswith materials variable physicomechanical or tissues tissues and organs, needs one materials variablewith physicomechanical characteristics, characteristics, which cause minimum tissue [2,3,4].material. Due to the specifics of its production and destruction, the basic places in the its and destruction, PLA occupies one of the PLA basicoccupies places inone theof series of biocompatible series of biocompatible and used biodegradable polymers usedand in plastic regenerative and plastic and biodegradable polymers in regenerative medicine surgerymedicine for reconstruction of surgery reconstruction of bone and PLA cartilage defects [5,6].polymer
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