Abstract
Photoacoustic (PA) imaging is a methodology that uses the absorption of short laser pulses by endogenous or exogenous chromophores within human tissue, and the subsequent generation of acoustic waves acquired by an ultrasound (US) transducer, to form an image that can provide functional and molecular information. Amongst the various types of PA imaging, PA tomography (PAT) has been proposed for imaging pathologies such as breast cancer. However, the main challenge for PAT imaging is the deliverance of sufficient light energy horizontally through an imaging cross-section as well as vertically. In this study, three different illumination methods are compared for a full-ring ultrasound (US) PAT system. The three distinct illumination setups are full-ring, diffused-beam, and point source illumination. The full-ring system utilizes a cone mirror and parabolic reflector to create the ringed-shaped beam for PAT, while the diffuse scheme uses a light diffuser to expand the beam, which illuminates tissue-mimicking phantoms. The results indicate that the full-ring illumination is capable of providing a more uniform fluence irrespective of the vertical depth of the imaged cross-section, while the point source and diffused illumination methods provide a higher fluence at regions closer to the point of entry, which diminishes with depth. In addition, a set of experiments was conducted to determine the optimum position of ring-illumination with respect to the position of the acoustic detectors to achieve the highest signal-to-noise ratio.
Highlights
Breast cancer is a significant health problem in the United States but globally and was the second leading cause of cancer-related death in the United States in 2018 [1]
Mammography, MRI (Magnetic Resonance Imaging), and B-mode ultrasound are the three most common imaging modalities used for breast cancer screening [2,3]
Using new findings from the three methods, it aims to show that full-ring illumination is the most effective method for creating PA tomography (PAT) images due to its inherent cross-sectional fluence uniformity across vertical imaging depths (Figure 1)
Summary
Breast cancer is a significant health problem in the United States but globally and was the second leading cause of cancer-related death in the United States in 2018 [1]. Mammography, MRI (Magnetic Resonance Imaging), and B-mode ultrasound are the three most common imaging modalities used for breast cancer screening [2,3]. Each of these modalities has its own unique shortcomings. This could make it difficult to access areas close methodology. Compared in this study, with the definitions of vertical and cross-sectional imaging depths
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