Photoacoustic effect and controlled release of azo and Schiff base derivatives modified by click reagents under the NIR light

Abstract

PurposeThis study aims to develop a new kind of functional low molecular weight organic dyes, which is highly efficient, meanwhile inexpensive and easily prepared and modified and can be used in photoacoustic (PA) imaging and photothermal therapy (PTT). To further realize the release of molecules under the biomedical condition, the releasing efficiency of micellar nanoparticles under different stimuli were represented.Design/methodology/approachA class of azo and Schiff base derivatives with different click reagents were characterized by PA imaging and photothermal (PT) experiments. The molecule with best PT effect was loaded into a temperature-stimuli-sensitive amphiphilic block copolymer which demonstrated the capability of releasing the polymers under the near-infrared (NIR) light of 650 nm.FindingsThe PA and PT effects of a series of azo and Schiff base derivatives with different click reagents were characterized. Introducing the click reagent F4-TCNQ can result in red shift of peaks of PA intensity. Stimulated with 650 nm laser irradiation, the polymer processed higher release rate than being stimulated by temperature stimuli.Practical implicationsThis paper not only guides the design of NIR dyes with good PA intensity but also provides a method which has great potential for the application of NIR photothermal dyes in the field of biotechnology for controlled release.Originality/valueThis paper uses click reagents to modify azo and Schiff derivatives and an amphiphilic block copolymer under NIR light to realize controlled release.