Abstract
Medical imaging through a targeting agent promises to improve the specificity and sensitivity of cancer detection. Nanoparticles (NPs) may provide advantages for targeted photoacoustic (PA) imaging due to their unique physical and optical properties. In our previous study, we developed a phase-change contrast agent made from a biodegradable polymer, poly(lactic-co-glycolic acid) (PLGA) and loaded with perfluorohexane (PFH) liquid, gold NPs and fluorescent dyes for PA imaging and cancer therapy [1]. In this study, The PLGA NPs were conjugated to an anti-HER2 antibody (Herceptin) for specific binding to breast cancer cells that overexpress HER2 receptors. The targeting specificity of PLGA-GNR-Herceptin NPs and the resultant PA enhancement in cells were examined using fluorescent imaging, flow cytometry, and PA imaging.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
