Abstract
Changes in kidney calcium concentration and secreted parathyroid hormone were studied in weanling male rats (n = 12) fed diets containing either 0.5% (n = 6) or 1.5% (n = 6) total phosphorus. Calcium and phosphorus concentrations in the kidney of rats fed a high-phosphorus diet were markedly greater than those in rats fed a control diet. In addition, urinary excretion of phosphorus increased gradually after administration of a high-phosphorus diet, but there was no similar tendency of phosphorus/creatinine excretion, which decreased gradually from the starting day of feeding to the end of the feeding period. The high-phosphorus diet also produced greater serum parathyroid hormone (PTH) without urinary cyclic adenosine monophosphate (cAMP) excretion stimulated by PTH. The mean values of serum 1,25-dihydroxycholecalciferol (1,25(OH)2D3) concentrations were significantly increased 1 h after injection of 2.77 μg rat PTH(1–34) in all rats. However, in rats fed a high-phosphorus diet, the rise of serum 1,25(OH)2D stimulated by exogenous PTH was lower than that in rats fed a control diet.
Published Version
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