Abstract
The synthesis of a possible intermediate in phosphonolipid metabolism, viz. L-α-glyceryl-(2-trimethylammoniumethyl)phosphonate, a phosphonic acid analogue of L-α-glycerylphosphorylcholine, is described. The compound was obtained by condensation of D-acetone glycerol with (2-bromoethyl)metaphosphonate in boiling benzene, removal of the acetone group of the condensation product by acid hydrolysis, treatment of the hydrolysis product in dimethylformamide with trimethylamine at 60–62° for 3 days, isolation of L-α-glyceryl-(2-trimethylammoniumethyl)phosphate as cadmium chloride complex. Removal of the cadmium chloride was effected with a mixture of Amberlites IR-45 and IRC-50. A procedure for the preparation of (2-bromoethyl)metaphosphonate is reported.
Published Version
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