PHOSPHOLIPASE A 2 , PLASMA ELASTASE ACTIVITY IN PRE- AND POST-PARTUM OF PRE-ECLAMPTIC WOMEN

Abstract

ABSTRACTObjective: The objectives of the present study were to evaluate the activity of phospholipase A2, plasma elastase enzymes and to assess relation withan inflammatory marker high sensitive C-reactive protein (hs-CRP) in nonpregnant before and after delivery of normotensive pregnant and preeclampticwomen.Methods: The study population consists of three groups: Nonpregnant (Group 1, n=57), normotensive pregnant (Group 2, n=57), and pre-eclampticwomen (Group 3, n=57). Groups 2 and 3 were followed after delivery within 48 hrs. Phospholipase A, plasma elastase, and hs-CRP levels weredetermined spectrophotometrically.Results: The plasma elastase, phospholipase A22 activity, and hs-CRP were elevated in pre-eclampsia significantly (p<0.05), nonsignificant rise innormotensive pregnant before delivery condition compared to nonpregnant women. However, plasma elastase in normal pregnancy and pre-eclampsiawere decreased by 1.2- and 2.07-fold, respectively, after delivery. Whereas phospholipase A and hs-CRP found to be nonsignificantly decreased in thepostdelivery status of the both the groups. Receiver operating characteristics curve analysis showed that elastase enzyme has diagnostic importanceto assess inflammation on the basis of area under curve (0.758).2Conclusion: Our research findings generated knowledge about raised level of plasma elastase enzyme by neutrophil degranulation representsinflammation in pre-eclampsia. Elevated elastase, phospholipase AKeywords: Elastase, High sensitive C - reactive protein, Phospholipase A2 with hs-CRP in pre-eclampsia serves as indicators of inflammation., Pre-eclampsia.