Abstract
AbstractThe effect of extracellular Pi and arsenate on Pi‐transport in Ehrlich ascites tumor cells has been studied. Pi‐transport can be described by Michaelis‐Menten kinetics; the maximal flux equal to 44 mmoles (kg cell water)−1 hour−1 and Km equal to 3.3 × 10−4 M. Arsenate is a competitive inhibitor of Pi‐transport with an inhibition constant (Ki) equal to 2.41 × 10−3 M.The data support the hypothesis that cellular Pi is regulated by the cell membrane through the mediation of a carrier system.
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