Phosgene-free synthesis of polypeptides using activated urethane derivatives of α-amino acids: an efficient synthetic approach to hydrophilic polypeptides

Shuhei Yamada,Takeshi Endo,Mitsuaki Goto,Atsushi Sudo

doi:10.1039/c4ra03315a

Phosgene-free synthesis of polypeptides using activated urethane derivatives of α-amino acids: an efficient synthetic approach to hydrophilic polypeptides

Shuhei Yamada, Takeshi Endo + Show 2 more

https://doi.org/10.1039/c4ra03315a

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Journal: RSC Adv.	Publication Date: Jan 1, 2014
Citations: 27

Affiliation: Kindai University

#Activated Urethane Derivatives #Elimination Of Phenol #Elimination Of CO2 #Polypeptide Synthesis #Derivatives Of Acids #Efficient Approach #Derivatives Of Α-amino Acids #Phosgene-free Synthesis #Urethane Derivatives #Hydrophilic Polypeptides

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Polypeptide synthesis has been successfully achieved through polycondensation of activated urethane derivatives with amines, accompanied by the elimination of phenol and CO2.

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Phosgene-free synthesis of polypeptides using activated urethane derivatives of α-amino acids: an efficient synthetic approach to hydrophilic polypeptides