Abstract
L'auteur discute et présente, à la lumière des douze observations actuellement connues, la revue générale des problèmes fondamentaux soulevés par le phénotype Rh nul, en particulier son déterminisme génétique, ses inter-relations phénotypiques et le défaut associé de l'intégrité de la membrane érythrocytaire. Some fundamental problems of the Rh null phenotype, especially its genetic pathways, its phenotypic interactions and the associated red cell membrane defect, are discussed in the light of data obtained from the twelve so far known families.
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