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Abstract
1. 1. Phloretin non-competitively inhibits glucose and methionine absorption by Hymenolepis diminuta ( K i = 0.24 and 1.48 mM, respectively). 2. 2. Inhibition of glucose transport by phloretin is reversible. 3. 3. Phloretin and phlorizin binding sites on the surface of H. diminuta are distinct. 4. 4. Phloretin does not inhibit Na + transport independent of glucose transport in H. diminuta. 5. 5. The data suggest that phloretin inhibits absorptive functions across the surface of H. diminuta via non-specific binding sites associated with the lipid portion of the worm outer membrane.
Published Version
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