Abstract
Background Resistance to antimicrobial agents is prevalent among Staphylococci. This has led to wide uses of macrolide-lincosamide-streptogramin B (MLSB) antibiotics to Staphylococcus aureus (S. aureus) infections. MLSB though chemically distinct, have similar target site and mode of action. The multiple mechanisms are responsible for resistance to MLSB antibiotics which can lead to clinical failure. The aim of the study was to investigate the frequency of inducible and constitutive clindamycin resistance among clinical isolates of S. aureus and their relationship with Methicillin-resistant Staphylococcus aureus (MRSA).Material & Methods A total of 336 unique Staphylococcus aureus isolates from different clinical samples obtained from patients were studied. Antibiotic susceptibility test was performed by Kirby- Bauer disc diffusion method. āD testā was performed to detect inducible clindamycin resistance as per CLSI guidelines. MRSA was detected using Cefoxitin (30Ī¼g) and results were interpreted according to CLSI criteria.Results Inducible clindamycin resistance was seen in 45 (13.39%), constitutive clindamycin resistance was seen among 58 (17.26%) while MS phenotype was observed among 38(11.30%) of isolates. Inducible resistance as well as constitutive resistance was higher among MRSA as compared to MSSA (21.11%, 4.48% and 21.11%, 12.82%respectively).Conclusion The Successful use of clindamycin for the treatment of infection caused by S. aureus can be predicted based on the result of simple and inexpensive D test.Journal of Nobel Medical CollegeVolume 5, Number 1, Issue 8, January-July 2016, 1-5
Highlights
Staphylococcus aureus (S. aureus) is one of the most frequent microorganisms responsible for both community and hospital acquired infections
Constitutively resistance Staphylococcus aureus are resistant to both erythromycin and clindamycin whereas those with inducible resistance are resistant to erythromycin and appear sensitive to clindamycin [6]
Prevalence of inducible as well as constitutive resistance was higher among Methicillin-resistant Staphylococcus aureus (MRSA) as compared to MSSA (Chi-square test, p < 0.001) [Table 2]
Summary
Staphylococcus aureus (S. aureus) is one of the most frequent microorganisms responsible for both community and hospital acquired infections. Which are resistance to multiple classes of antibiotics often pose problems in therapy This has renewed concern for the usage of Macrolide-Lincosamide-Streptogramin B (MLSB) antibiotics to treat S. aureus infections [1]. The objective of the present study was to investigate the prevalence of inducible clindamycin resistance among Staphylococcus aureus isolated from our teaching hospital and to detect their distribution among Methicillinresistant Staphylococcus aureus (MRSA). Resistance to antimicrobial agents is prevalent among Staphylococci This has led to wide uses of macrolide-lincosamide-streptogramin B (MLSB) antibiotics to treat Staphylococcus aureus (S. aureus) infections. The multiple mechanisms are responsible for resistance to MLSB antibiotics which can lead to clinical failure. The aim of the study was to investigate the frequency of inducible and constitutive clindamycin resistance among clinical isolates of S. aureus and their relationship with Methicillin-resistant Staphylococcus aureus (MRSA). MRSA was detected using Cefoxitin (30Ī¼g) and results were interpreted according to CLSI criteria
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