Abstract
The resistance to antimicrobial agents among Staphylococci is an increasing problem. Clinical laboratories should perform D test routinely to guide the clinicians about the inducible clindamycin resistance and to prevent misuse of antibiotics. Study aimed to isolates the Inducible and Constitutive clindamycin Resistance in Staphylococcus aureus in various clinical samples. We analyzed the performance of disk diffusion method in 183 Staphylococci aureus strains obtained from various clinical samples of the patients collected from September 2018 to February 2020 at a tertiary care centre, Meerut. Inducible clindamycin resistance was tested by ‘D test’ as per CLSI guidelines. 142(77.6%) of isolates were found to be methicillin resistant (MRSA) and 41 (22.4%) tested sensitive to cefoxitin i.e., methicillin sensitive (MSSA). Inducible resistance and constitutive resistance were found to be higher in MRSA as compared to MSSA). The D test method showed to be simple and easy in the detection of inducible (iMLS) and constitutive clindamycin resistance (cMLS).
Highlights
Staphylococcus aureus is one of the most common pyogenic bacteria infecting man
Community-acquired methicillin-resistant S. aureus (CA-methicilin resistant S. aureus (MRSA)), which has rapidly emerged in recent years as a cause of skin and soft-tissue infections, is frequently susceptible to several antibiotics, including clindamycin. 2,3
This study was aimed to assess the prevalence and antimicrobial susceptibility pattern of methicillin and induced clindamycin-resistant Staphylococcus aureus from various clinical samples received in tertiary care centre, Meerut, North India
Summary
Staphylococcus aureus is one of the most common pyogenic bacteria infecting man. The determination of antimicrobial susceptibility of a clinical isolate is often crucial for optimal antimicrobial therapy of infected patients. Emergence of methicillin resistance in Staphylococcus aureus has left us with very few therapeutic alternatives available to treat Staphylococcal infections. Staphylococcus aureus, one of the most common nosocomial and communityacquired pathogens has emerged as an everincreasing problem due to its increasing resistance to several antibiotics. Clindamycin is an alternative drug for infections due to Staphylococcus aureus in case of intolerance to penicillin or resistance to methicillin. Community-acquired methicillin-resistant S. aureus (CA-MRSA), which has rapidly emerged in recent years as a cause of skin and soft-tissue infections, is frequently susceptible to several antibiotics, including clindamycin. Clinical laboratories should perform D test routinely to guide the clinicians about the inducible clindamycin resistance and to prevent misuse of antibiotics. Aims: Study aimed to isolates the Inducible and Constitutive clindamycin Resistance in Staphylococcus aureus in various clinical samples. The D test method showed to be simple and easy in the detection of inducible (iMLSB) and constitutive clindamycin resistance (cMLSB)
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